My main perspective in OmniFocus is called the Dashboard and this is where I spend 95% of my time in the app.
It’s a list view of everything that is available and flagged or due soon. It also contains my daily GTD tasks and daily routine things (like publishing a blog post).
I could bore you with the details on how to set it up, but I took it from Joe Buhlig’s site, so I’ll give hime all the credit 🙂
The system works well for me and I try to keep the number items on my dashboard to one page without scrolling, or about 25 items.